To breathe or not to breathe: Understanding how oxygen sensing contributes to age-related phenotypes

نویسندگان

چکیده

Aging is characterized by a progressive loss of tissue integrity and functionality due to disrupted homeostasis. Molecular oxygen pivotal maintain functions, aerobic species have evolved sophisticated sensing system ensure proper supply demand. It not surprising that aberrations in oxygen-associated pathways subvert health promote different aspects aging. In this review, we discuss emerging findings on how oxygen-sensing mechanisms regulate cellular molecular processes during normal physiology, dysregulation availability lead disease We describe various clinical manifestations associated with deregulation balance, oxygen-modulating therapies natural oscillations influence longevity. conclude discussing better understanding oxygen-related orchestrate aging may the development new therapeutic strategies extend healthy

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ژورنال

عنوان ژورنال: Ageing Research Reviews

سال: 2021

ISSN: ['1872-9649', '1568-1637']

DOI: https://doi.org/10.1016/j.arr.2021.101267